Na+,K+-ATPase activity in the cochlear lateral wall of the gerbil

Masayuki Furukawa, Katsuhisa Ikeda, Syunji Takeuchi, Takeshi Oshima, Toshihiko Kikuchi, Tomonori Takasaka

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We examined Na+,K+-ATPase activity in four regions of the gerbil cochlear lateral wall by measuring intracellular Na+ concentration ([Na+](i)). The application of 1 mM ouabain and removal of external K+ caused a most striking increase in [Na+l(i) of the suprastrial fibrocytes, followed by the stria vascularis and the type II fibrocytes, but no detectable response in the type I fibrocytes. These results may imply the potency of the Na+,K+-ATPase activity. The high values of the resting [Na+](i) in these cells under perilymph-like solution returned to the [Na+](i) within physiological values after exposure to low-Na+ conditions similar to endolymph. Our results are interpreted in the light of recent morphological findings with regard to the roles in the secretion of K+ into endolymph of several cell types within the lateral wall.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalNeuroscience Letters
Volume213
Issue number3
DOIs
Publication statusPublished - 1996 Aug 9
Externally publishedYes

Keywords

  • Cochlear lateral wall
  • Fibrocytes
  • Intracellular Na concentrations
  • Na,K-ATPase
  • Stria vascularis

ASJC Scopus subject areas

  • Neuroscience(all)

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