Abstract
We report here a novel carrier of quantum dots (QDs) for intracellular labeling. Monodisperse hybrid nanoparticles (38 nm in diameter) of QDs were prepared by simple mixing with nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH2). The CHPNH2-QD nanoparticles were effectively internalized into the various human cells examined. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.
Original language | English |
---|---|
Pages (from-to) | 917-921 |
Number of pages | 5 |
Journal | Biochemical and biophysical research communications |
Volume | 331 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2005 Jun 17 |
Externally published | Yes |
Keywords
- Bioimaging
- Carrier
- Cationic liposome
- Cellular uptake
- Cholesterol-bearing pullulan
- Live cell labeling
- Nanogel
- Quantum dot
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology