Nanogel-quantum dot hybrid nanoparticles for live cell imaging

Urara Hasegawa, Shin Ichiro M. Nomura, Sunil C. Kaul, Takashi Hirano, Kazunari Akiyoshi

Research output: Contribution to journalArticlepeer-review

170 Citations (Scopus)

Abstract

We report here a novel carrier of quantum dots (QDs) for intracellular labeling. Monodisperse hybrid nanoparticles (38 nm in diameter) of QDs were prepared by simple mixing with nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH2). The CHPNH2-QD nanoparticles were effectively internalized into the various human cells examined. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.

Original languageEnglish
Pages (from-to)917-921
Number of pages5
JournalBiochemical and biophysical research communications
Volume331
Issue number4
DOIs
Publication statusPublished - 2005 Jun 17
Externally publishedYes

Keywords

  • Bioimaging
  • Carrier
  • Cationic liposome
  • Cellular uptake
  • Cholesterol-bearing pullulan
  • Live cell labeling
  • Nanogel
  • Quantum dot

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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