Nanogel engineered designs for polymeric drug delivery

Nobuyuki Morimoto, Shin Ichiro M. Nomura, Naomi Miyazawa, Kazunari Akiyoshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

Functional nanogels and hydrogels, based on self-assembly of associating polymers, were designed for novel drug delivery applications. In particular, hydrophobized polysaccharides such as cholesteryl-bearing pullulans form physically crosslinked nanogels by self-assembly. These nanogels trap hydrophobic molecules (antitumor drugs), proteins (enzymes, insulin, antigen protein), and nucleic acids (DNA plasmids), and therefore, can be used as polymeric nanocarriers in cancer chemotherapy, protein delivery, and artificial vaccines. Stimuli-responsive nanogels such as pH-responsive, thermo-responsive, and photoresponsive nanogels were also designed using a similar self-assembly method. Macrogels with welldefined nanostructures were obtained by self-assembly, utilizing these nanogels as building blocks. The self-assembly method based on associating polymers is an efficient and versatile technique for the preparation of functional nanogels and hydrogels.

Original languageEnglish
Title of host publicationPolymeric Drug Delivery II Polymeric Matrices and Drug Particle Engineering
EditorsSoenke Svenson
Pages88-101
Number of pages14
Publication statusPublished - 2006 Dec 1
Externally publishedYes

Publication series

NameACS Symposium Series
Volume924
ISSN (Print)0097-6156

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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