Cholesteryl-group bearing pullulans (CHP)s form stable monodispersive nanogels (20-30 nm) by inter-macromolecular self-association in water. We reported that CHP nanogels were useful for drug carrier and artificial molecular chaperon. In this study, we prepared thermo-responsive hydrogel composed of methacrylate-bearing CHP nanogel as a crosslinker and N-isopropylacrylamide (NIPA) as a thermo-responsive unit in semi-dilute aqueous solution. Thermo-responsibility of the hydrogel was evaluated by the weight reduction from 20Z°C to 40°C. The CHP-NIPA hydrogel showed remarkable rapid deswelling behavior (Figure 2). The deswelling of the hydrogel was due to the volume phase transition at a lower critical solution temperature (LCST) of PNIPA. The multi-crosslinking by nanogels significantly affected the deswelling kinetics of PNIPA gels.
|Number of pages||1|
|Publication status||Published - 2005 Dec 1|
|Event||54th SPSJ Symposium on Macromolecules - Yamagata, Japan|
Duration: 2005 Sep 20 → 2005 Sep 22
|Other||54th SPSJ Symposium on Macromolecules|
|Period||05/9/20 → 05/9/22|
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