Nanogel-crosslinked thermo-rasponsive hydrogels: Synthesis and function

Takafumi Ohki, Nobuyuki Morimoto, Kimio Kurita, Kazunari Akiyosi

Research output: Contribution to conferencePaperpeer-review


Cholesteryl-group bearing pullulans (CHP)s form stable monodispersive nanogels (20-30 nm) by inter-macromolecular self-association in water. We reported that CHP nanogels were useful for drug carrier and artificial molecular chaperon. In this study, we prepared thermo-responsive hydrogel composed of methacrylate-bearing CHP nanogel as a crosslinker and N-isopropylacrylamide (NIPA) as a thermo-responsive unit in semi-dilute aqueous solution. Thermo-responsibility of the hydrogel was evaluated by the weight reduction from 20Z°C to 40°C. The CHP-NIPA hydrogel showed remarkable rapid deswelling behavior (Figure 2). The deswelling of the hydrogel was due to the volume phase transition at a lower critical solution temperature (LCST) of PNIPA. The multi-crosslinking by nanogels significantly affected the deswelling kinetics of PNIPA gels.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22


Other54th SPSJ Symposium on Macromolecules


  • Hydrogel
  • N-isopropylacrylamide
  • Nanogel
  • Self-assembly
  • Thermo-responsive

ASJC Scopus subject areas

  • Engineering(all)


Dive into the research topics of 'Nanogel-crosslinked thermo-rasponsive hydrogels: Synthesis and function'. Together they form a unique fingerprint.

Cite this