Nanocrystallization mechanism of organic compounds in the reprecipitation method by stopped-flow analysis

Daniel Oliveira, Koichi Baba, Junichi Mori, Yousuke Miyashita, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Nanoparticle formation by the reprecipitation method for three different types of aromatic compounds was investigated by monitoring induced spectral changes using the stopped-flow technique. The rate of nanocrystallization was determined under different conditions, as temperature, concentration, and type of solvent were systematically varied. It turned out qualitatively that on the millisecond order, nanocrystal growth is governed by the classical nucleation theory. It was found that the supersaturation ratio, and thus the solubility of the organic compound in a water/organic solvent mixture, is a key factor in understanding the kinetics of organic nanoparticle formation. Therefore, careful control of the supersaturation ratio is critical when controlling nanoparticle formation.

Original languageEnglish
Pages (from-to)1050031-1050035
Number of pages5
JournalJapanese journal of applied physics
Volume48
Issue number10 Part 1
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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