Nanoparticle formation by the reprecipitation method for three different types of aromatic compounds was investigated by monitoring induced spectral changes using the stopped-flow technique. The rate of nanocrystallization was determined under different conditions, as temperature, concentration, and type of solvent were systematically varied. It turned out qualitatively that on the millisecond order, nanocrystal growth is governed by the classical nucleation theory. It was found that the supersaturation ratio, and thus the solubility of the organic compound in a water/organic solvent mixture, is a key factor in understanding the kinetics of organic nanoparticle formation. Therefore, careful control of the supersaturation ratio is critical when controlling nanoparticle formation.
ASJC Scopus subject areas
- Physics and Astronomy(all)