Nano-droplet-seeded sonodynamic tumor treatment with dye sensitizer

Ken Ichi Kawabata, Takashi Maruoka, Rei Asami, Akihide Wada, Yasuteru Muragaki, Shinichiro Umemura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Phase-change nano-droplet (PCND) was found to promote cavitation and aid the active oxygen generation by sonochemical agents. PCNDs, which are droplets containing superheated perfluorocarbon, were suspended in buffer solution with a dye sensitizer, Rose Bengal (RB). Samples were exposed to 1.1-MHz ultrasound with a sequence consisting of pulses for generating microbubbles and continuous waves for inducing cavitational effects. The yield of reactive oxygen species (ROS) by ultrasound exposures, measured as the increase of fluorescence intensity of a fluorescein derivative was strongly dependent on the interval of the pulses. It was found that pulse intervals shorter than 0.03 s were needed to generate ROS. Further, we found that RB works not only for generating ROS but also for inducing cavitation. Because PCNDs have been revealed to significantly reduce cavitation threshold both in vitro and in vivo, the combination of PCNDs and dye sensitizers may lead to a sonodynamic tumor treatment method with reduced ultrasound energy and improved reproducibility.

Original languageEnglish
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Number of pages4
Publication statusPublished - 2012 Dec 1
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: 2012 Oct 72012 Oct 10

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


Other2012 IEEE International Ultrasonics Symposium, IUS 2012


  • cavitation
  • nano droplet
  • phase-change
  • rose bengal
  • sonodynamic treatment

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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