Abstract
Two new cytotoxic compounds, nakiterpiosin (1) and nakiterpiosinone (2), were isolated from the Okinawan sponge Terpios hoshinota. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin (1) and nakiterpiosinone (2) showed potent cytotoxicity against mouse lymphocytic leukemia cell (P388).
Original language | English |
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Pages (from-to) | 6989-6993 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 60 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2004 Aug 9 |
Externally published | Yes |
Keywords
- C-nor-D-homosteroid
- Cytotoxicity
- Nakiterpiosin
- Nakiterpiosinone
- The sponge Terpios hoshinota
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry