Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroids from the Okinawan sponge Terpios hoshinota

Toshiaki Teruya; Satoru Nakagawa; Tomoyuki Koyama; Hirokazu Arimoto; Masaki Kita; Daisuke Uemura

doi:10.1016/j.tet.2003.08.083

Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroids from the Okinawan sponge Terpios hoshinota

Toshiaki Teruya, Satoru Nakagawa, Tomoyuki Koyama, Hirokazu Arimoto, Masaki Kita, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Two new cytotoxic compounds, nakiterpiosin (1) and nakiterpiosinone (2), were isolated from the Okinawan sponge Terpios hoshinota. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin (1) and nakiterpiosinone (2) showed potent cytotoxicity against mouse lymphocytic leukemia cell (P388).

Original language	English
Pages (from-to)	6989-6993
Number of pages	5
Journal	Tetrahedron
Volume	60
Issue number	33
DOIs	https://doi.org/10.1016/j.tet.2003.08.083
Publication status	Published - 2004 Aug 9
Externally published	Yes

Keywords

C-nor-D-homosteroid
Cytotoxicity
Nakiterpiosin
Nakiterpiosinone
The sponge Terpios hoshinota

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroids from the Okinawan sponge Terpios hoshinota",

abstract = "Two new cytotoxic compounds, nakiterpiosin (1) and nakiterpiosinone (2), were isolated from the Okinawan sponge Terpios hoshinota. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin (1) and nakiterpiosinone (2) showed potent cytotoxicity against mouse lymphocytic leukemia cell (P388).",

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AU - Nakagawa, Satoru

AU - Koyama, Tomoyuki

AU - Arimoto, Hirokazu

AU - Kita, Masaki

AU - Uemura, Daisuke

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KW - Nakiterpiosinone

KW - The sponge Terpios hoshinota

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