Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroids from the Okinawan sponge Terpios hoshinota

Toshiaki Teruya, Satoru Nakagawa, Tomoyuki Koyama, Hirokazu Arimoto, Masaki Kita, Daisuke Uemura

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Two new cytotoxic compounds, nakiterpiosin (1) and nakiterpiosinone (2), were isolated from the Okinawan sponge Terpios hoshinota. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin (1) and nakiterpiosinone (2) showed potent cytotoxicity against mouse lymphocytic leukemia cell (P388).

Original languageEnglish
Pages (from-to)6989-6993
Number of pages5
JournalTetrahedron
Volume60
Issue number33
DOIs
Publication statusPublished - 2004 Aug 9
Externally publishedYes

Keywords

  • C-nor-D-homosteroid
  • Cytotoxicity
  • Nakiterpiosin
  • Nakiterpiosinone
  • The sponge Terpios hoshinota

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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