N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Sträussler syndrome

Tetsuyuki Kitamoto, Tamaki Muramoto, Caroline Hilbich, Konrad Beyreuther, Jun Tateishi

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Kuru plaques are one of the pathological hallmarks in Gerstmann-Sträussler syndrome, and are composed of prion protein (PrP). To elucidate whether N-terminal sequence of Prp is related to amygdaloid formation in vivo, we prepared antibody against synthetic N-terminal peptide (anti-PrP-N). Anti-PrP-N immunolabeled kuru plaques positively. Positive reactions were observed in the periphery of large kuru plaque cores, but not in the center. It is therefore postulated that one of the modification of Prp is N-terminal truncation.

Original languageEnglish
Pages (from-to)319-321
Number of pages3
JournalBrain research
Volume545
Issue number1-2
DOIs
Publication statusPublished - 1991 Apr 5
Externally publishedYes

Keywords

  • Gerstmann-Sträussler syndrome
  • Kuru plaque
  • N-Terminal
  • Prion protein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Sträussler syndrome'. Together they form a unique fingerprint.

Cite this