N-terminal pro-B-type natriuretic peptide is not a significant predictor of stroke incidence after 5 years ― The Ohasama study ―

Michihiro Satoh, Takahisa Murakami, Kei Asayama, Takuo Hirose, Masahiro Kikuya, Ryusuke Inoue, Megumi Tsubota-Utsugi, Keiko Murakami, Ayako Matsuda, Azusa Hara, Taku Obara, Ryo Kawasaki, Kyoko Nomura, Hirohito Metoki, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

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5 Citations (Scopus)


Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been used for risk stratification in heart failure or acute coronary syndrome, but the beyond 5-year predictive value of NT-proBNP for stroke remains an unsettled issue in Asian patients. The aim of the present study was to clarify this point. Methods and Results: We followed 1,198 participants (33.4% men; mean age, 60.5±11.1 years old) in the Japanese general population for a median of 13.0 years. A first stroke occurred in 93 participants. Referencing previous reports, we stratified participants according to NT-proBNP 30.0, 55.0, and 125.0 pg/mL. Using the NT-proBNP <30.0 pg/mL group as a reference, adjusted HR for stroke (95% CI) in the NT-proBNP 30.0–54.9-pg/mL, 55.0–124.9-pg/mL, and ≥125.0-pg/mL groups were 1.92 (0.94–3.94), 1.77 (0.85–3.66), and 1.99 (0.86–4.61), respectively. With the maximum follow-up period set at 5 years, the hazard ratio of the NT-proBNP≥125.0-pg/mL group compared with the <30.0-pg/mL group increased significantly (HR, 4.51; 95% CI: 1.03–19.85). On extension of the maximum follow-up period, however, the association between NT-proBNP and stroke risk weakened. Conclusions: NT-proBNP was significantly associated with an elevated stroke risk. Given, however, that the predictive power decreased with the number of years after NT-proBNP measurement, NT-proBNP should be re-evaluated periodically in Asian patients.

Original languageEnglish
Pages (from-to)2055-2062
Number of pages8
JournalCirculation Journal
Issue number8
Publication statusPublished - 2018


  • Epidemiology
  • N-terminal pro-B-type natriuretic peptide
  • Prevention
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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