N-[18F]Fluoroacetyl-D-glucosamine: A potential agent for cancer diagnosis

T. Fujiwara, K. Kubota, T. Sato, T. Matsuzawa, M. Tada, Ren Iwata, M. Itoh, J. Hatazawa, K. Sato, H. Fukuda, T. Ido

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18 Citations (Scopus)

Abstract

Positron labeled substrates such as sugars, amino acids, and nucleosides have been investigated for the in-vivo evaluation of biochemical processes in cancerous tissue. Hexosamines are obligatory structural components of many biologically important macromolecules, including membrane glycoproteins and mucopolysaccharide. We evaluated a new synthesized pharmaceutical, N-[18F]fluoroacetyl-D-glucosamine (18F-FAG), which is a structural analog of N-acetyl-D-glucosamine. C3H/HeMsNRS mice bearing spontaneous hepatomas were used for the tissue distribution study. At 60 min after injection, high uptakes were found in tumor (5.16, mean value of %dose/g), liver (3.71), and kidney (3.27). The tumor uptake of 18F-FAG showed the highest value in all tissues. In the PET study, VX-2 carcinoma of the rabbit was clearly visualized. Our preliminary results suggest that 18F-FAG has potential as a new agent for tumor imaging.

Original languageEnglish
Pages (from-to)1654-1658
Number of pages5
JournalJournal of Nuclear Medicine
Volume31
Issue number10
Publication statusPublished - 1990 Jan 1

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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