TY - JOUR
T1 - N-(F-18)-Flouoroacetyl-D-Glucosamine
T2 - A New Positron Labeled Pharmaceutical for Cancer Study
AU - Fujiwara, Takehiko
AU - Itoh, Masatoshi
AU - Kubota, Kazuo
AU - Sato, Tachio
AU - Takahashi, Jutarou
AU - Abe, Yoshinao
AU - Fukuda, Hiroshi
AU - Tada, Masao
AU - Iwata, Ren
AU - Ido, Tatsuo
AU - Sato, Kazunori
PY - 1992
Y1 - 1992
N2 - In order to evaluate the role of hexosamine metabolism in tumor tissue, we studied the biodistribution of N-(F-18)- fluoroacetyl-D-glucosamine (FAGlu) in male Donryu rats bearing poorly differentiated hepatomas (AH109A and AH272). Compare with the former result of the high tumor uptake of FAGlu in C3H/He mice bearing well differentiated spontaneous hepatoma, the tumor uptakes of FAGlu in these tumors showed the lower values. This suggested that spontaneous hepatoma maintained a high activity of glucosamine metabolism, while poorly differentiated hepatoma had little activity. Metabolism of glucosamine in tumor tissue may be another marker for characterizing tumors. We also discuss the tissue distribution of new F-18 labeled hexosamines, N-(F-18)-fluoroacetyl-D-mannosamine and N-(F-18)- fluoroacetyl-D-galactosamine in tumor bearing rats.
AB - In order to evaluate the role of hexosamine metabolism in tumor tissue, we studied the biodistribution of N-(F-18)- fluoroacetyl-D-glucosamine (FAGlu) in male Donryu rats bearing poorly differentiated hepatomas (AH109A and AH272). Compare with the former result of the high tumor uptake of FAGlu in C3H/He mice bearing well differentiated spontaneous hepatoma, the tumor uptakes of FAGlu in these tumors showed the lower values. This suggested that spontaneous hepatoma maintained a high activity of glucosamine metabolism, while poorly differentiated hepatoma had little activity. Metabolism of glucosamine in tumor tissue may be another marker for characterizing tumors. We also discuss the tissue distribution of new F-18 labeled hexosamines, N-(F-18)-fluoroacetyl-D-mannosamine and N-(F-18)- fluoroacetyl-D-galactosamine in tumor bearing rats.
KW - N-(F-18)- fluoroacetyl-D-galactosamine
KW - N-(F-18)- fluoroacetyl-D-glucosamine
KW - N-(F-18)-fluoroacetyl-D-mannosamine
KW - hepatoma
KW - tissue distribution
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UR - http://www.scopus.com/inward/citedby.url?scp=0026969975&partnerID=8YFLogxK
U2 - 10.1620/tjem.168.317
DO - 10.1620/tjem.168.317
M3 - Article
C2 - 1306316
AN - SCOPUS:0026969975
VL - 168
SP - 317
EP - 321
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 2
ER -
