Myriad functions of stanniocalcin-1 (STC1) cover multiple therapeutic targets in the complicated pathogenesis of idiopathic pulmonary fibrosis (IPF)

Shinya Ohkouchi, Manabu Ono, Makoto Kobayashi, Taizou Hirano, Yutaka Tojo, Shu Hisata, Masakazu Ichinose, Toshiya Irokawa, Hiromasa Ogawa, Hajime Kurosawa

Research output: Contribution to journalReview articlepeer-review

Abstract

Idiopathic pulmonary fibrosis (IPF) is an intractable disease for which the pathological findings are characterized by temporal and spatial heterogeneity. The pathogenesis is composed of myriad factors, including repetitive injuries to epithelial cells, alterations in immunity, the formation of vascular leakage and coagulation, abnormal wound healing, fibrogenesis, and collagen accumulation. Therefore, the molecular target drugs that are used or attempted for treatment or clinical trials may not cover the myriad therapeutic targets of IPF. In addition, the complicated pathogenesis results in a lack of informative biomarkers to diagnose accurately the status of IPF. These facts point out the necessity of using a combination of drugs, that is, each single drug with molecular targets or a single drug with multiple therapeutic targets. In this review, we introduce a humoral factor, stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep epithelial and endothelial homeostasis, which may adequately cover the myriad therapeutic targets of IPF.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalClinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
Volume2015
DOIs
Publication statusPublished - 2015

Keywords

  • Biomarker
  • Idiopathic pulmonary fibrosis (IPF)
  • Macrophage
  • Stanniocalcin-1 (STC1)
  • Wound healing

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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