Myeloid Derived Suppressor Cells

Taku Fujimura, Alexander H. Enk

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Myeloid derived suppressor cells (MDSCs) comprise a phenotypically heterogeneous population of cells, which can be found in tumor bearing mice and in patients with cancer. MDSCs play a central role in the induction of peripheral tolerance. Together with regulatory T cells (Tregs) they promote an immunosuppressive environment in tumor-bearing hosts. In addition, MDSCs convert into M2 like tumor-associated macrophages (TAMs) in the tumor to establish an immunosuppressive, tumor microenvironment. In peripheral blood organs, MDSCs contribute to systemic tolerance by producing immunomodulatory cytokines (e.g. IL-10, TGFβ). The phenotype of MDSCs differs in humans and mice, and the exact mechanisms of their suppressive function are still controversially discussed. In summary, MDSCs are a group of phenotypically heterogeneous cells of myeloid origin that have common biological activities. In this section, we discuss the definition of MDSCs, the proposed mechanisms of expansion and the recruitment and activation of MDSCs, as well as their biological activities in tumor bearing hosts to assess the potential therapeutic applications.

Original languageEnglish
Title of host publicationImmunology of the Skin
Subtitle of host publicationBasic and Clinical Sciences in Skin Immune Responses
PublisherSpringer Japan
Pages179-192
Number of pages14
ISBN (Electronic)9784431558552
ISBN (Print)9784431558538
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Keywords

  • Immunosuppressive macrophages
  • Myeloid derived suppressor cells
  • Peripheral tolerance
  • Regulatory T cells
  • Tumor associated macrophages
  • Tumor microenvironment

ASJC Scopus subject areas

  • Engineering(all)

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