Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy

Takaaki Nakamura, Kimihiko Kaneko, Genya Watanabe, Shogo Harashima, Emiko Kawasaki, Kenichi Tsukita, Toshiyuki Takahashi, Ichiro Nakashima, Tatsuro Misu, Yasushi Suzuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Myelin oligodendrocyte glycoprotein (MOG)-IgG detected by the cell-based assay is associated with demyelinating diseases of the central nervous system, such as optic neuritis, myelitis, and acute disseminated encephalomyelitis, but rarely with peripheral neuropathy. Here, we describe the case of a 32-year-old MOG-IgG+ woman who developed central and peripheral demyelinating lesions. In contrast to previous similar cases, she uniquely presented with repeated subsequent relapses in the peripheral nerve, mimicking chronic inflammatory demyelinating polyneuropathy. Possible pathogenic implications of MOG-IgG in combined central and peripheral nervous system diseases are considered.

Original languageEnglish
Pages (from-to)1135-1138
Number of pages4
JournalNeurological Sciences
Volume42
Issue number3
DOIs
Publication statusPublished - 2021 Mar

Keywords

  • Combined central and peripheral demyelination
  • Delivery
  • Myelin oligodendrocyte glycoprotein
  • Myelitis
  • Radiculitis
  • Relapse

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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