Abstract
Mycothiol is found in Gram-positive bacteria, where it helps in maintaining a reducing intracellular environment and it plays an important role in protecting the cell from toxic chemicals. The inhibition of the mycothiol biosynthesis is considered as a treatment for tuberculosis. Mycothiol contains an α-aminoglycoside, which is difficult to prepare stereoselectively by a conventional glycosylation reaction. In this study, mycothiol was synthesized by an anomerization reaction from an easily prepared β-aminoglycoside through endocyclic cleavage.
Original language | English |
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Pages (from-to) | 328-333 |
Number of pages | 6 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 12 |
DOIs | |
Publication status | Published - 2016 Feb 22 |
Externally published | Yes |
Keywords
- Aminoglycoside
- Anomerization
- Endocyclic cleavage reaction
- Inositol
- Mycothiol
ASJC Scopus subject areas
- Organic Chemistry