Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line

Liushiqi Borjigin, Tomoyuki Shimazu, Yuki Katayama, Kouichi Watanabe, Haruki Kitazawa, Sang Gun Roh, Hisashi Aso, Kazuo Katoh, Takafumi Uchida, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

To understand the influence of crossbreeding on Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics, two crossbred lines were characterized. One crossbred line, LaWa, was generated by crossing the MPS pulmonary lesion selected Landrace line (La) and the highly immune-selected Large White line (Wa). The second crossbred line, LaWb, was generated by crossing the La line and the nonselected Large White line (Wb). The crossbred LbWb line (nonselected Landrace line × nonselected Large White line) and the La line were used as controls. The LaWa and LaWb lines had an intermediate level of MPS lung lesions between La and LbWb lines, although the difference was not statistically significant. After stimulation with sheep red blood cells (SRBCs), the LaWb and LaWa lines showed immune characteristics similar to that of the La line; the number of monocytes in peripheral blood increased, while B cells, T cells, secretion of SRBC-specific immunoglobulin G, and interleukin (IL)-13 decreased. Additionally, the number of natural killer (NK) cells and the expression of IL-4 and IL-17 were significantly higher in the LaWb and LaWa lines, respectively. These data suggested that crossbreeding of La and Wa lines resulted in the inheritance of some of the selected immune responses.

Original languageEnglish
Pages (from-to)972-981
Number of pages10
JournalAnimal science journal = Nihon chikusan Gakkaiho
Volume87
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1

Keywords

  • crossbred pig
  • disease resistance
  • immunogenic properties
  • mycoplasma pneumonia lesions

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line'. Together they form a unique fingerprint.

Cite this