Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease

Takashi Hirama; Alex Marchand-Austin; Jennifer Ma; David C. Alexander; Sarah K. Brode; Theodore K. Marras; Frances B. Jamieson

doi:10.1007/s00408-018-0087-9

Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease

Takashi Hirama, Alex Marchand-Austin, Jennifer Ma, David C. Alexander, Sarah K. Brode, Theodore K. Marras, Frances B. Jamieson

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Through a prospective study for M. xenopi strain type and the relation to clinical phenotype, 39 patients with M. xenopi PD were analyzed. Our study demonstrated that sequence type (ST) 5 was dominant in Ontario among 15 distinct STs and caused PD in people even without underlying lung disease, whereas disease due to non-ST5 was found almost exclusively in patients with underlying lung disease.

Original language	English
Pages (from-to)	213-217
Number of pages	5
Journal	Lung
Volume	196
Issue number	2
DOIs	https://doi.org/10.1007/s00408-018-0087-9
Publication status	Published - 2018 Apr 1
Externally published	Yes

Keywords

MLST
Mycobacterial disease
Mycobacterium xenopi
Non-tuberculous mycobacteria

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1007/s00408-018-0087-9

Cite this

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title = "Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease",

abstract = "Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Through a prospective study for M. xenopi strain type and the relation to clinical phenotype, 39 patients with M. xenopi PD were analyzed. Our study demonstrated that sequence type (ST) 5 was dominant in Ontario among 15 distinct STs and caused PD in people even without underlying lung disease, whereas disease due to non-ST5 was found almost exclusively in patients with underlying lung disease.",

keywords = "MLST, Mycobacterial disease, Mycobacterium xenopi, Non-tuberculous mycobacteria",

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AU - Hirama, Takashi

AU - Marchand-Austin, Alex

AU - Ma, Jennifer

AU - Alexander, David C.

AU - Brode, Sarah K.

AU - Marras, Theodore K.

AU - Jamieson, Frances B.

PY - 2018/4/1

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AB - Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Through a prospective study for M. xenopi strain type and the relation to clinical phenotype, 39 patients with M. xenopi PD were analyzed. Our study demonstrated that sequence type (ST) 5 was dominant in Ontario among 15 distinct STs and caused PD in people even without underlying lung disease, whereas disease due to non-ST5 was found almost exclusively in patients with underlying lung disease.

KW - MLST

KW - Mycobacterial disease

KW - Mycobacterium xenopi

KW - Non-tuberculous mycobacteria

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Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease

Abstract

Keywords

ASJC Scopus subject areas

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