TY - JOUR
T1 - Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease
AU - Hirama, Takashi
AU - Marchand-Austin, Alex
AU - Ma, Jennifer
AU - Alexander, David C.
AU - Brode, Sarah K.
AU - Marras, Theodore K.
AU - Jamieson, Frances B.
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Through a prospective study for M. xenopi strain type and the relation to clinical phenotype, 39 patients with M. xenopi PD were analyzed. Our study demonstrated that sequence type (ST) 5 was dominant in Ontario among 15 distinct STs and caused PD in people even without underlying lung disease, whereas disease due to non-ST5 was found almost exclusively in patients with underlying lung disease.
AB - Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Through a prospective study for M. xenopi strain type and the relation to clinical phenotype, 39 patients with M. xenopi PD were analyzed. Our study demonstrated that sequence type (ST) 5 was dominant in Ontario among 15 distinct STs and caused PD in people even without underlying lung disease, whereas disease due to non-ST5 was found almost exclusively in patients with underlying lung disease.
KW - MLST
KW - Mycobacterial disease
KW - Mycobacterium xenopi
KW - Non-tuberculous mycobacteria
UR - http://www.scopus.com/inward/record.url?scp=85040783355&partnerID=8YFLogxK
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U2 - 10.1007/s00408-018-0087-9
DO - 10.1007/s00408-018-0087-9
M3 - Article
C2 - 29349535
AN - SCOPUS:85040783355
VL - 196
SP - 213
EP - 217
JO - Pneumonologie. Pneumonology
JF - Pneumonologie. Pneumonology
SN - 0341-2040
IS - 2
ER -