Mutual Binding Inhibition of Tetrodotoxin and Saxitoxin to Their Binding Protein from the Plasma of the Puffer Fish, Fugu pardalis

Mari Yotsu-Yamashita, Yuki Shoji, Takahiro Terakawa, Shunichi Yamada, Teruo Miyazawa, Takeshi Yasumoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of Fugu pardalis was investigated by HPLC. The values for the half inhibitory concentration of tetrodotoxin (1.6 μM) binding to this protein (1.2 μM) for saxitoxin, and of saxitoxin (0.47 μM) binding to that (0.30 μM) for tetrodotoxin were 0.35±0.057 μM and 81±16 μM (n=2), respectively.

Original languageEnglish
Pages (from-to)2520-2524
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number11
DOIs
Publication statusPublished - 2002 Jan 1

Keywords

  • Binding protein
  • Mutual inhibition
  • Puffer fish
  • Saxitoxin
  • Tetrodotoxin

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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