Mutations of the p53 gene, including an intronic point mutation, in colorectal tumors

Chikashi Ishioka, Toshiaki Sato, Makio Gamoh, Takao Suzuki, Hiroyuki Shibata, Ryunosuke Kanamaru, Akira Wakui, Tadasu Yamazaki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.

Original languageEnglish
Pages (from-to)901-906
Number of pages6
JournalBiochemical and biophysical research communications
Volume177
Issue number3
DOIs
Publication statusPublished - 1991 Jun 28

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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