Mutations of the p53 gene in adult T-cell leukemia

A. Sakashita, T. Hattori, C. W. Miller, H. Suzushima, N. Asou, K. Takatsuki, H. P. Koeffler

Research output: Contribution to journalArticlepeer-review

201 Citations (Scopus)

Abstract

The p53 tumor suppressor gene was examined by direct sequencing of polymerase chain reaction-amplified DNA from fresh tumor cells of 10 patients with adult T-cell leukemia (ATL). Samples included nine patients with acute or lymphomatous ATL, and one patient in whom samples were examined in both his acute and chronic stages of ATL. Four missense mutations and one silent point mutation in the coding region of the p53 gene were found in cells from five patients with either acute or lymphomatous ATL. The missense mutations were homozygous and occurred in evolutionarily highly conserved regions of p53. One patient had no p53 mutation in his leukemic cells during chronic phase of ATL, but had a homozygous point mutation at codon 273 (Arg to His) when he progressed to acute ATL. In summary, we show that p53 is frequently mutated in the acute phase of ATL and one informative case suggests that p53 mutations may be associated with the transition from chronic to acute ATL.

Original languageEnglish
Pages (from-to)477-480
Number of pages4
JournalBlood
Volume79
Issue number2
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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