Mutations of the Epstein-Barr virus LMP-1 oncogene in a 10-year-old Japanese girl with nasopharyngeal carcinoma

Y. Ohashi, M. Minegishi, H. Fujie, S. Tsuchiya, Ryo Ichinohasama, T. Konno

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 10-year-old patient with nasopharyngeal carcinoma (NPC) was studied for mutations within the carboxy-terminal portion of the Epstein-Barr virus (EBV) latent membrane protein (LMP)-1 gene. The EBV genome, defined as type A, was detected in biopsied tumor specimens by Southern hybridization with specific probes. Sequence analysis of the carboxy-terminal part of the LMP-1 gene revealed no deletions but seven single-base substitutions, four of which were found to be identical to those previously detected in codons for amino acids 322 to 366 in the Chinese NPC CAO. Although yet unresolved, the observed mutations may be associated with the pathogenesis of NPC.

Original languageEnglish
Pages (from-to)1376-1379
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume85
Issue number11
DOIs
Publication statusPublished - 1996 Jan 1

Keywords

  • Epstein-Barr virus
  • LMP-1
  • Mutations
  • Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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