Mutations in hepatitis B virus core regions correlate with hepatocellular injury in Chinese patients with chronic hepatitis B

Hiroto Tanaka, Hiroki Ueda, Hiroko Hamagami, Susumu Yukawa, Masakazu Ichinose, Motoshige Miyano, Keiji Mimura, Iwao Nishide, Bo Xin Zhang, Su Wen Wang, Shi Oing Zhou, Bei Hai Li

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2 Citations (Scopus)

Abstract

Aim: To elucidate the relationship between the frequency of core mutations and the clinical activity of hepatitis B virus (HBV)-related liver disease and to characterize the amino acid changes in the core region of HBV. Methods: We studied 17 Chinese patients with chronic hepatitis B according to their clinical courses and patterns of the entire core region of HBV. Results: Amino acid changes often appeared in the HBV core region of the HBV gene in patients with high values of alanine aminotransferase (ALT) or with the seroconversion from HbeAg to anti-HBe. The HBV core region with amino acid changes had high frequency sites that corresponded to HLA I/II restricted recognition epitopes reported by some investigators. Conclusion: The core amino acid changes of this study occur due to influence of host immune system. The presence of mutations in the HBV core region seems to be important for predicting the clinical activity of hepatitis B in Chinese patients.

Original languageEnglish
Pages (from-to)4693-4696
Number of pages4
JournalWorld Journal of Gastroenterology
Volume11
Issue number30
DOIs
Publication statusPublished - 2005 Aug 14

Keywords

  • Activity
  • Chronic hepatitis B
  • Core region
  • DNA sequences
  • HBe antigen
  • Hepatitis B virus
  • Mutation
  • Serum ALT

ASJC Scopus subject areas

  • Gastroenterology

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    Tanaka, H., Ueda, H., Hamagami, H., Yukawa, S., Ichinose, M., Miyano, M., Mimura, K., Nishide, I., Zhang, B. X., Wang, S. W., Zhou, S. O., & Li, B. H. (2005). Mutations in hepatitis B virus core regions correlate with hepatocellular injury in Chinese patients with chronic hepatitis B. World Journal of Gastroenterology, 11(30), 4693-4696. https://doi.org/10.3748/wjg.v11.i30.4693