Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila

Julien Séjourn, Pierre Yves Plaçais, Yoshinori Aso, Igor Siwanowicz, Séverine Trannoy, Vladimiros Thoma, Stevanus R. Tedjakumala, Gerald M. Rubin, Paul Tchénio, Kei Ito, Guillaume Isabel, Hiromu Tanimoto, Thomas Preat

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129 Citations (Scopus)

Abstract

Aversive olfactory memory is formed in the mushroom bodies in Drosophila melanogaster. Memory retrieval requires mushroom body output, but the manner in which a memory trace in the mushroom body drives conditioned avoidance of a learned odor remains unknown. To identify neurons that are involved in olfactory memory retrieval, we performed an anatomical and functional screen of defined sets of mushroom body output neurons. We found that MB-V2 neurons were essential for retrieval of both short- and long-lasting memory, but not for memory formation or memory consolidation. MB-V2 neurons are cholinergic efferent neurons that project from the mushroom body vertical lobes to the middle superiormedial protocerebrum and the lateral horn. Notably, the odor response of MB-V2 neurons was modified after conditioning. As the lateral horn has been implicated in innate responses to repellent odorants, we propose that MB-V2 neurons recruit the olfactory pathway involved in innate odor avoidance during memory retrieval.

Original languageEnglish
Pages (from-to)903-910
Number of pages8
JournalNature Neuroscience
Volume14
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Séjourn, J., Plaçais, P. Y., Aso, Y., Siwanowicz, I., Trannoy, S., Thoma, V., Tedjakumala, S. R., Rubin, G. M., Tchénio, P., Ito, K., Isabel, G., Tanimoto, H., & Preat, T. (2011). Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila. Nature Neuroscience, 14(7), 903-910. https://doi.org/10.1038/nn.2846