TY - JOUR
T1 - Murine double minute 2 and its association with chemoradioresistance of esophageal squamous cell carcinoma
AU - Okamoto, Hiroshi
AU - Fujishima, Fumiyoshi
AU - Nakamura, Yasuhiro
AU - Zuguchi, Masashi
AU - Miyata, Go
AU - Kamei, Takashi
AU - Nakano, Toru
AU - Katsura, Kazunori
AU - Abe, Shigeo
AU - Taniyama, Yusuke
AU - Teshima, Jin
AU - Watanabe, Mika
AU - Sato, Akira
AU - Ohuchi, Noriaki
AU - Sasano, Hironobu
PY - 2013/4
Y1 - 2013/4
N2 - Background: Definitive chemoradiotherapy (dCRT) has been established as the standard treatment for esophageal squamous cell carcinoma (ESCC). However, many patients develop persistent or recurrent disease following dCRT. We investigated factors related to chemoradioresistance and treatment outcomes in patients with ESCC who underwent salvage esophagectomy after dCRT. Patients and Methods: We selected 38 patients with persistent disease and 24 with recurrent disease who underwent salvage esophagectomy after dCRT, immunolocalized p53, p16, p27, murine double minute 2 (MDM2), cyclin D1, Ki-67, and epidermal growth factor receptor, and correlated the findings with clinicopathological features. Results: MDM2 positivity was significantly higher among patients with persistent disease than among those with recurrent disease (p<0.0001). In addition, negative p16 expression was a predictor of poor prognosis among patients with persistent disease. Conclusion: MDM2 overexpression plays an important role in chemoradioresistance of ESCC; furthermore, negative p16 expression can predict poor prognosis of patients with persistent disease.
AB - Background: Definitive chemoradiotherapy (dCRT) has been established as the standard treatment for esophageal squamous cell carcinoma (ESCC). However, many patients develop persistent or recurrent disease following dCRT. We investigated factors related to chemoradioresistance and treatment outcomes in patients with ESCC who underwent salvage esophagectomy after dCRT. Patients and Methods: We selected 38 patients with persistent disease and 24 with recurrent disease who underwent salvage esophagectomy after dCRT, immunolocalized p53, p16, p27, murine double minute 2 (MDM2), cyclin D1, Ki-67, and epidermal growth factor receptor, and correlated the findings with clinicopathological features. Results: MDM2 positivity was significantly higher among patients with persistent disease than among those with recurrent disease (p<0.0001). In addition, negative p16 expression was a predictor of poor prognosis among patients with persistent disease. Conclusion: MDM2 overexpression plays an important role in chemoradioresistance of ESCC; furthermore, negative p16 expression can predict poor prognosis of patients with persistent disease.
KW - Definitive chemoradiotherapy
KW - Esophagus
KW - Ki-67
KW - Murine double minute 2
KW - P16
KW - Salvage esophagectomy
KW - Squamous cell carcinoma
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M3 - Article
C2 - 23564787
AN - SCOPUS:84876776104
SN - 0250-7005
VL - 33
SP - 1463
EP - 1472
JO - Anticancer Research
JF - Anticancer Research
IS - 4
ER -
