Murine and Human T-Lymphocyte GATA-3 Factors Mediate Transcription through a cis-Regulatory Element within the Human T-Cell Receptor δ Gene Enhancer

Linda J. Ko, Masayuki Yamamoto, Mark W. Leonard, Kathleen M. George, Paul Ting, James Douglas Engel

Research output: Contribution to journalArticle

221 Citations (Scopus)

Abstract

A family of transcriptional activators has recently been identified in chickens; these transcriptional activators recognize a common consensus motif (WGATAR) through a conserved C4 zinc finger DNA-binding domain. One of the members of this multigene family, cGATA-3, is most abundantly expressed in the T-lymphocyte cell lineage. Analysis of human and murine GATA-3 factors shows a striking degree of amino acid sequence identity and similar patterns of tissue specificity of expression in these three organisms. The murine and human factors are abundantly expressed in a variety of human and murine T-cell lines and can activate transcription through a tissue-specific GATA-binding site identified within the human T-cell receptor δ gene enhancer. We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation.

Original languageEnglish
Pages (from-to)2778-2784
Number of pages7
JournalMolecular and cellular biology
Volume11
Issue number5
DOIs
Publication statusPublished - 1991 May

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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