Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

Shinsuke Taki, Takeo Sato, Kouetsu Ogasawara, Taeko Fukuda, Mitsuharu Sato, Shigeaki Hida, Gen Suzuki, Masao Mitsuyama, Eun Hee Shin, Soumei Kojima, Tadatsugu Taniguchi, Yoshihiro Asano

Research output: Contribution to journalArticlepeer-review

302 Citations (Scopus)

Abstract

Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice tacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.

Original languageEnglish
Pages (from-to)673-679
Number of pages7
JournalImmunity
Volume6
Issue number6
DOIs
Publication statusPublished - 1997 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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