Multiple‐hormone gene expression in ganglioneuroblastoma with watery diarrhea, hypokalemia, and achlorhydria syndrome

Noriko Kimura, Hiroshi Yamamoto, Hiroshi Okamoto, Haruki Wakasa, Hiroshi Nagura

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Background. It has been reported that vasoactive intestinal peptide (VIP)–producing tumors accompanied by watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome often produce multiple hormones biochemically and immunohistochemically. Methods. The authors examined the distribution of several peptides—VIP, peptide histidine methionine (PHM), neuropeptide Y (NPY), methionine–enkephalin (M‐EK), somatostatin (SS), substance‐P (Sub‐P), corticotropin‐releasing hormone, and tyrosine hydroxylase—with immunohistochemical studies and an in situ hybridization method in three ganglioneuroblastomas with WDHA syndrome. All patients had an extremely elevated plasma level of VIP. Results. Peptides examined immunohistochemically in the tumor were all detectable in ganglionic cells and some neurites. The coexistence of those peptides was observed with serial section staining. The presence of messenger RNA of VIP/PHM‐27, NPY, and SS was detectable in the cytoplasm of the tumor cells with the in situ hybridization. Conclusions. It was shown that multiple genes of peptides are expressed simultaneously and translated to proteins in those tumors.

Original languageEnglish
Pages (from-to)2841-2846
Number of pages6
JournalCancer
Volume71
Issue number9
DOIs
Publication statusPublished - 1993 May 1

Keywords

  • achlorhydria syndrome
  • ganglioneuroblastoma
  • gene
  • hypokalemia
  • messenger RNA
  • peptide hormone
  • watery diarrhea

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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