TY - JOUR
T1 - Multiple symptoms of higher brain dysfunction caused by Marchiafava-Bignami disease in a patient with dermatomyositis
AU - Furukawa, Kanako
AU - Maeshima, Etsuko
AU - Maeshima, Shinichiro
AU - Ichinose, Masakazu
PY - 2011/1
Y1 - 2011/1
N2 - A 65-year-old woman with dermatomyosi tis (DM) was admitted because of disorientation, mental dysfunction, and disturbance of consciousness. Prior to admission, she suffered from septic and hypovolemic shock. There was no evidence of active DM on physical examination and laboratory tests. Cerebrospinal fluid examination revealed no signs of meningitis. Because of clinical symptoms and findings on magnetic resonance images, such as the lesion in the splenium of the corpus callosum that was a low-intensity area on T1-weighted images and a high intensity on T2-weighted images; she was diagnosed as Marchiafava-Bignami disease (MBD). She received a combination of vitamin B, vitamin E, vitamin C, and nicotinic acid. Her symptoms improved gradually, and she was discharged at 1.5 months after admission. There has been no report of a case of DM with MBD. This report may provide useful data with regard to the mechanisms of central nervous system (CNS) disorders in patients with DM.
AB - A 65-year-old woman with dermatomyosi tis (DM) was admitted because of disorientation, mental dysfunction, and disturbance of consciousness. Prior to admission, she suffered from septic and hypovolemic shock. There was no evidence of active DM on physical examination and laboratory tests. Cerebrospinal fluid examination revealed no signs of meningitis. Because of clinical symptoms and findings on magnetic resonance images, such as the lesion in the splenium of the corpus callosum that was a low-intensity area on T1-weighted images and a high intensity on T2-weighted images; she was diagnosed as Marchiafava-Bignami disease (MBD). She received a combination of vitamin B, vitamin E, vitamin C, and nicotinic acid. Her symptoms improved gradually, and she was discharged at 1.5 months after admission. There has been no report of a case of DM with MBD. This report may provide useful data with regard to the mechanisms of central nervous system (CNS) disorders in patients with DM.
KW - Dermatomyositis
KW - Higher brain dysfunction
KW - Magnetic resonance images
KW - Marchiafava-Bignami disease
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U2 - 10.1007/s00296-009-1164-4
DO - 10.1007/s00296-009-1164-4
M3 - Article
C2 - 19847434
AN - SCOPUS:78751582227
VL - 31
SP - 109
EP - 112
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 1
ER -