Multiple Squamous Cell Carcinomas of the Head and Neck Show Different Phenotypes of Allelic Loss Patterns Suggesting Different Clonal Origin of Carcinogenesis

Kiyoto Shiga, Takenori Ogawa, Fumiaki Yoshida, Kazuto Matsuura, Masaru Tateda, Shigeru Saijo, Taeko Miyagi, Toshimitsu Kobayashi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: Multiple squamous cell carcinomas in the head and neck are not such a rare phenomenon in patients. To examine if these tumors have the same genetic basis or not, we investigated genetic alterations such as allelic loss in such multiple tumors to see if they showed identical patterns. Materials and Methods: Patterns of the loss of heterozygosity at 3p, 9p and 17p loci were analyzed in multiple head and neck squamous cell carcinomas of the same patient. Results: Metachronous laryngeal and tongue tumors of a patient were found to have identical patterns of allelic loss, while synchronous tumors of three other patients had different patterns of such loss. Conclusion: Our data support the idea that field carcinogenesis caused by exposure of oral, laryngeal and pharyngeal mucosa to carcinogens may lead to the independent development of synchronous non-related tumors at different sites of the upper aerodigestive tract.

Original languageEnglish
Pages (from-to)3911-3915
Number of pages5
JournalAnticancer research
Volume23
Issue number5 A
Publication statusPublished - 2003 Sep 1

Keywords

  • Field carcinogenesis
  • Head and neck squamous cell carcinoma
  • Loss of heterozygosity
  • Multiple cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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