Multiple specificities of brain Ca2+- and calmodulin-dependent protein kinase for substrate

Kohji Fukunaga, Hideyuki Yamamoto, Yasushi Iwasa, Eishichi Miyamoto

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The purified Ca2+- and calmodulin-dependent protein kinase from rat brain, which has a M.W. of 120,000 by gel filtration analysis, showed a broad substrate specificity. In addition to myosin light chain from chicken gizzard, the enzyme phosphorylated myelin basic protein, casein and two endogenous substrates in a Ca2+- and calmodulin-dependent manner. In contrast, chicken gizzard myosin light chain kinase exclusively phosphorylated myosin light chain.

Original languageEnglish
Pages (from-to)2019-2024
Number of pages6
JournalLife Sciences
Issue number23
Publication statusPublished - 1982 Jun 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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