Multiple mechanisms for hereditary sideroblastic anemia.

Kazumichi Furuyama, Shigeru Sassa

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Hereditary sideroblastic anemia (HSA) is a heterogeneous group of inherited anemic disorders which is characterized by the presence of ringed sideroblasts in the bone marrow, microcytic hypochromic anemia and typically its X-linked inheritance in patients. It has been shown that a deficiency of the erythroid-specific delta-aminolevulinate synthase (ALAS-E) activity is responsible for pyridoxine-responsive HSA in many patients, however, the pathogenesis of other types of HSA remains still unknown. In this article, recent evidence suggesting multiple causes for HSA is summarized and discussed.

Original languageEnglish
Pages (from-to)5-10
Number of pages6
JournalCellular and molecular biology (Noisy-le-Grand, France)
Volume48
Issue number1
Publication statusPublished - 2002 Feb

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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