Abstract
Hereditary sideroblastic anemia (HSA) is a heterogeneous group of inherited anemic disorders which is characterized by the presence of ringed sideroblasts in the bone marrow, microcytic hypochromic anemia and typically its X-linked inheritance in patients. It has been shown that a deficiency of the erythroid-specific delta-aminolevulinate synthase (ALAS-E) activity is responsible for pyridoxine-responsive HSA in many patients, however, the pathogenesis of other types of HSA remains still unknown. In this article, recent evidence suggesting multiple causes for HSA is summarized and discussed.
Original language | English |
---|---|
Pages (from-to) | 5-10 |
Number of pages | 6 |
Journal | Cellular and molecular biology (Noisy-le-Grand, France) |
Volume | 48 |
Issue number | 1 |
Publication status | Published - 2002 Feb |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology