Multimodal strategy for managing meningiomas in the elderly

Yukihiko Sonoda, K. Sakurada, M. Saino, R. Kondo, S. Sato, T. Kayama

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Background. The incidence of brain tumors in elderly patients is increasing. It has become possible to treat meningiomas in the elderly by several modalities. We developed a successful multimodal strategy to treat these patients. Methods. We registered 35 patients with meningiomas. Symptomatic meningiomas were treated surgically at the time of diagnosis (n = 19). Of the 16 asymptomatic meningiomas, 5 were removed at the time of diagnosis. The other asymptomatic meningiomas (n = 11) were treated conservatively and when the tumors increased in size, surgical treatment was considered. "Operated" patients with residual or recurrent tumors underwent radiosurgery with a gamma knife. Findings. Surgical mortality and morbidity were 4% and 16%, respectively. Of the 25 "operated" patients, 21 (84.0%) had a good Karnofsky scale (≥80%) at discharge. In all but two of the 11 patients with asymptomatic, conservatively treated meningiomas, the tumors did not increase during the follow-up period. Gamma knife radiosurgery, performed to treat 3 residual and 1 recurrent tumor, resulted in very good tumor control and none of the tumors increased after gamma knife surgery. Conclusions. Meningiomas in elderly patients require a multimodal approach. Our strategy, which includes surgery, radiosurgery, and conservative treatment, resulted in good tumor control and made it possible for patients to pursue their activities of daily life.

    Original languageEnglish
    Pages (from-to)131-136
    Number of pages6
    JournalActa neurochirurgica
    Volume147
    Issue number2
    DOIs
    Publication statusPublished - 2005 Feb 1

    Keywords

    • Asymptomatic
    • Elderly patients
    • Gamma knife
    • Meningioma

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology

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