Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits

Hajime Mushiake; Tomokazu Ohshiro; Shin Ichiro Osawa; Ryosuke Hosaka; Norihiro Katayama; Tetsu Tanaka; Hiromu Yawo; Makoto Osanai

doi:10.1007/978-981-15-8763-4_34

Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits

Hajime Mushiake, Tomokazu Ohshiro, Shin Ichiro Osawa, Ryosuke Hosaka, Norihiro Katayama, Tetsu Tanaka, Hiromu Yawo, Makoto Osanai

Research output: Contribution to journal › Article › peer-review

Abstract

To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.

Original language	English
Pages (from-to)	501-509
Number of pages	9
Journal	Advances in experimental medicine and biology
Volume	1293
DOIs	https://doi.org/10.1007/978-981-15-8763-4_34
Publication status	Published - 2021

Keywords

Barrel cortex
Entrainment
Hippocampus
Opto-current clamp
Resonance
Seizure

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/978-981-15-8763-4_34

Fingerprint Dive into the research topics of 'Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits'. Together they form a unique fingerprint.

Cite this

Multimodal Functional Analysis Platform : 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits. / Mushiake, Hajime ; Ohshiro, Tomokazu ; Osawa, Shin Ichiro; Hosaka, Ryosuke; Katayama, Norihiro ; Tanaka, Tetsu; Yawo, Hiromu; Osanai, Makoto.

In: Advances in experimental medicine and biology, Vol. 1293, 2021, p. 501-509.

Research output: Contribution to journal › Article › peer-review

@article{a85d226996c84563acf67c973bdcd57b,

title = "Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits",

abstract = "To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.",

keywords = "Barrel cortex, Entrainment, Hippocampus, Opto-current clamp, Resonance, Seizure",

author = "Hajime Mushiake and Tomokazu Ohshiro and Osawa, {Shin Ichiro} and Ryosuke Hosaka and Norihiro Katayama and Tetsu Tanaka and Hiromu Yawo and Makoto Osanai",

note = "Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine",

year = "2021",

doi = "10.1007/978-981-15-8763-4_34",

language = "English",

volume = "1293",

pages = "501--509",

journal = "Advances in Experimental Medicine and Biology",

issn = "0065-2598",

publisher = "Springer New York",

}

TY - JOUR

T1 - Multimodal Functional Analysis Platform

T2 - 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits

AU - Mushiake, Hajime

AU - Ohshiro, Tomokazu

AU - Osawa, Shin Ichiro

AU - Hosaka, Ryosuke

AU - Katayama, Norihiro

AU - Tanaka, Tetsu

AU - Yawo, Hiromu

AU - Osanai, Makoto

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2021

Y1 - 2021

N2 - To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.

AB - To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.

KW - Barrel cortex

KW - Entrainment

KW - Hippocampus

KW - Opto-current clamp

KW - Resonance

KW - Seizure

UR - http://www.scopus.com/inward/record.url?scp=85099332161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85099332161&partnerID=8YFLogxK

U2 - 10.1007/978-981-15-8763-4_34

DO - 10.1007/978-981-15-8763-4_34

M3 - Article

C2 - 33398837

AN - SCOPUS:85099332161

VL - 1293

SP - 501

EP - 509

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -