Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits

Hajime Mushiake, Tomokazu Ohshiro, Shin Ichiro Osawa, Ryosuke Hosaka, Norihiro Katayama, Tetsu Tanaka, Hiromu Yawo, Makoto Osanai

Research output: Contribution to journalArticlepeer-review

Abstract

To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.

Original languageEnglish
Pages (from-to)501-509
Number of pages9
JournalAdvances in experimental medicine and biology
Volume1293
DOIs
Publication statusPublished - 2021

Keywords

  • Barrel cortex
  • Entrainment
  • Hippocampus
  • Opto-current clamp
  • Resonance
  • Seizure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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