Abstract
To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.
Original language | English |
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Pages (from-to) | 501-509 |
Number of pages | 9 |
Journal | Advances in experimental medicine and biology |
Volume | 1293 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- Barrel cortex
- Entrainment
- Hippocampus
- Opto-current clamp
- Resonance
- Seizure
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)