@inbook{a85d226996c84563acf67c973bdcd57b,
title = "Multimodal functional analysis platform: 4. Optogenetics-induced oscillatory activation to explore neural circuits",
abstract = "To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.",
keywords = "Barrel cortex, Entrainment, Hippocampus, Opto-current clamp, Resonance, Seizure",
author = "Hajime Mushiake and Tomokazu Ohshiro and Osawa, {Shin ichiro} and Ryosuke Hosaka and Norihiro Katayama and Tetsu Tanaka and Hiromu Yawo and Makoto Osanai",
note = "Funding Information: Acknowledgments This work was supported by JSPS KAKENHI Grant Number JP16H06276 (Platform of Advanced Animal Model Support) and MEXT KAKENHI Grant Number 15H05879 (Non-linear Neuro-oscillology) and this research was supported by AMED under Grant Number JP19dm0207001. Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2021.",
year = "2021",
doi = "10.1007/978-981-15-8763-4_34",
language = "English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "501--509",
booktitle = "Advances in Experimental Medicine and Biology",
}