TY - JOUR
T1 - Multifocal BRAFV600E-Mutated Melanoma in situ on the Foot
AU - Iwama, Eimei
AU - Fujimura, Taku
AU - Kusakari, Yoshiyuki
AU - Haga, Takahiro
AU - Aiba, Setsuya
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Melanoma is an aggressive skin cancer that originates from melanocytes, and about one half of melanoma cases possess a BRAF mutation. Together with PD-L1 expression, the BRAFV600E mutation is one of the optimal therapeutic targets for the treatment of melanoma. In this report, we describe a case of multifocal melanoma in situ on the foot, which carried the p.V600E mutation in the BRAF gene. Interestingly, the spotted melanoma lesion is demarcated by normal skin, and in all spotted pigmented lesions, there were no signs of dermal invasion of melanoma cells or spontaneous regression. Our case presented atypical clinical features, which might correlate with the local mutations of BRAF gene and the immunological expression of PD-L1.
AB - Melanoma is an aggressive skin cancer that originates from melanocytes, and about one half of melanoma cases possess a BRAF mutation. Together with PD-L1 expression, the BRAFV600E mutation is one of the optimal therapeutic targets for the treatment of melanoma. In this report, we describe a case of multifocal melanoma in situ on the foot, which carried the p.V600E mutation in the BRAF gene. Interestingly, the spotted melanoma lesion is demarcated by normal skin, and in all spotted pigmented lesions, there were no signs of dermal invasion of melanoma cells or spontaneous regression. Our case presented atypical clinical features, which might correlate with the local mutations of BRAF gene and the immunological expression of PD-L1.
KW - BRAFmutation
KW - Malignant melanoma in situ
KW - PD-L1
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U2 - 10.1159/000441601
DO - 10.1159/000441601
M3 - Article
AN - SCOPUS:84955567259
VL - 7
SP - 322
EP - 327
JO - Case Reports in Dermatology
JF - Case Reports in Dermatology
SN - 1662-6567
IS - 3
ER -