TY - JOUR
T1 - Multifaceted mammalian transcriptome
AU - Carninci, Piero
AU - Yasuda, Jun
AU - Hayashizaki, Yoshihide
N1 - Funding Information:
We thank all the colleagues at RIKEN and in the FANTOM and Genome Network consortium for exciting discussions; Harumi Uruma for rendering secretary assistance in the preparation of the manuscript. Research grant for the RIKEN Genome Exploration Research Project from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government to YH; a grant of the Genome Network Project from the Ministry of Education, Culture, Sports, Science and Technology, Japan; grant for the RIKEN Frontier Research System, Functional RNA research program; and the grant from the 6th Framework of the EU (NFG) to PC.
PY - 2008/6
Y1 - 2008/6
N2 - Despite surprisingly a small number of protein-coding gene in mammalian genomes, a large variety of different RNAs is being produced. These RNAs are amazingly different in their number, size, cell localization, and mechanism of actions. Although new classes of short RNAs (sRNAs) are being continuously discovered, it is not yet obvious how many of the sRNAs are originated. Altogether, the research in the recent few years has identified an unexpectedly rich variety of mechanisms by which noncoding RNAs act, suggesting that we have identified probably only few of the many potential functional mechanism and more investigation will be needed to comprehensively understand the complex nature and biology of mammalian RNAome. Here, we focus on various aspects of the diversity of the biological role of these nonprotein-coding RNAs (ncRNAs), with emphasis on functional mechanisms recently elucidated.
AB - Despite surprisingly a small number of protein-coding gene in mammalian genomes, a large variety of different RNAs is being produced. These RNAs are amazingly different in their number, size, cell localization, and mechanism of actions. Although new classes of short RNAs (sRNAs) are being continuously discovered, it is not yet obvious how many of the sRNAs are originated. Altogether, the research in the recent few years has identified an unexpectedly rich variety of mechanisms by which noncoding RNAs act, suggesting that we have identified probably only few of the many potential functional mechanism and more investigation will be needed to comprehensively understand the complex nature and biology of mammalian RNAome. Here, we focus on various aspects of the diversity of the biological role of these nonprotein-coding RNAs (ncRNAs), with emphasis on functional mechanisms recently elucidated.
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U2 - 10.1016/j.ceb.2008.03.008
DO - 10.1016/j.ceb.2008.03.008
M3 - Review article
C2 - 18468878
AN - SCOPUS:44649151063
VL - 20
SP - 274
EP - 280
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 3
ER -