Multicentric reticulohistiocytosis in a child with sclerosing lesion of the leg: Immunohistopathologic studies and therapeutic trial with systemic cyclosporine

Yoko Kuramoto, Osamu Iizawa, Setsuya Aiba, Yoshio Makino, Hachiro Tagami

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Multicentric reticulohistiocytosis affecting a 13-year-old boy induced a sclerosing change of the leg. The cellular infiltrate comprising activated T lymphocytes and macrophages and human lymphocyte antigen (HLA)-DR expression by keratinocytes in lesional skin all suggest the involvement of cellular immune reactions. We administered systemic cyclosporine but could not obtain a favorable effect without a concomitant low dosage of prednisone

Original languageEnglish
Pages (from-to)329-335
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume20
Issue number2
DOIs
Publication statusPublished - 1989 Jan 1

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Multicentric reticulohistiocytosis in a child with sclerosing lesion of the leg: Immunohistopathologic studies and therapeutic trial with systemic cyclosporine'. Together they form a unique fingerprint.

Cite this