Multicentric lesions detected by the Light-induced Fluorescence Endoscope (LIFE). It's Usability and Limitation

Masami Sato, Motoyasu Sagawa, Akira Sakurada

Research output: Contribution to journalArticlepeer-review


Eighty patients were screened by the light-induced fluorescence endoscope (LIFE)-Lung System from November 1997 through April 1999. Thirty-seven cancerous lesions and 56 dysplastic lesions were detected by LIFE. Multicentric lesions including cancer or dysplasia were also detected. Out of 17 lung cancer patients with abnormal radiograms, five had multicentric lesions. Surprisingly, multiple lesions were diagnosed in 21 of 50 patients with positive or suspected-positive sputum cytology. In the present study, eight cancerous lesions could not be detected by the LIFE-Lung System. Since aspirates from the bronchial tree indicated the existence of cancer in these eight cases, differential brushing of all bronchi was performed and localization was determined. In six of eight patients, cancerous lesions were beyond the range of bronchoscopic visibility. By using a more slender scope (Olympus BF-P-40 or 3c40), three cancerous lesions were detected. On the other hand, retrospective analysis revealed that two cancerous lesions within bronchoscopic visibility showed loss of fluorescence. However, we were unable to notice these lesions as a specific finding indicating suspected cancer, because diffuse bronchitis resulted in many cold spots around the cancer.

Original languageEnglish
Pages (from-to)251-252
Number of pages2
JournalJapanese Journal of Chest Diseases
Issue number4
Publication statusPublished - 2000 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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