Multi-institutional Survey of Squamous Cell Carcinoma of the External Auditory Canal in Japan

Kiyoto Shiga, Ken ichi Nibu, Yasushi Fujimoto, Takahiro Asakage, Akihiro Homma, Hiroki Mitani, Takenori Ogawa, Kenji Okami, Shigeyuki Murono, Shigeru Hirano, Tsutomu Ueda, Nobuhiro Hanai, Kiyoaki Tsukahara, Ichiro Ota, Seiichi Yoshimoto, Takeshi Shinozaki, Shigemichi Iwae, Katsunori Katagiri, Daisuke Saito, Naomi KiyotaMakoto Tahara, Fumiaki Takahashi, Ryuichi Hayashi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Objectives: This study aimed to evaluate the efficacy of chemoradiotherapy (CRT) for patients with advanced cancer of the external auditory canal (EAC) by analyzing the outcome of the patients. Methods: This is a multi-institutional retrospective survey, and we reviewed the medical records of the subjects. A total of 181 patients with tumor (T)3 or T4 tumor in 17 institutions were enrolled. Further analysis was performed for 74 patients who underwent CRT under curative intent. Results: Overall 5-year survival rates of the patients who underwent CRT (n = 74) were 54.6%. Those of the patients who underwent CRT with modified TPF (docetaxel, cisplatin [CDDP], and 5-fluorouracil) regimen (n = 50) and CRT with CDDP regimens (n = 24) were 64.4% and 36.7%, respectively. Significant differences were observed between these two groups. Conclusion: Given the tendency that head and neck surgeons prefer CRT for advanced larger cancer of the EAC, CRT for advanced EAC cancer using the modified TPF regimen showed good clinical outcomes. Level of Evidence: 4 Laryngoscope, 131:E870–E874, 2021.

Original languageEnglish
Pages (from-to)E870-E874
Issue number3
Publication statusPublished - 2021 Mar


  • Squamous cell carcinoma, external auditory canal, chemoradiotherapy, multi-institutional study

ASJC Scopus subject areas

  • Otorhinolaryngology


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