Mucosal TBA reactants and glutathione levels in acute gastric mucosal injury in rats with obstructive jaundice

W. M. Shian, I. Sasaki, Y. Kamiyama, H. Naito, Y. Funayama, M. Takahashi, A. Iwatuki, S. Matsuno

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

This study is designed to determine whether free radicals are contributing factors in the pathogenesis of AGML in jaundiced rats following water-immersion-restraint stress (WIRS). Methods: Male Sprague-Dawley rats weighing approximately 200 g were divided into 3 groups: A. sham-operated (control) rats, B. jaundiced (bile duct ligated) rats, C. jaundiced rats with drainage, and the following measured: 1 Ulcer index (UI), 1 Thiobarbituric acid (TAB) reactants in gastric mucosa, 3 Total glutathione in gastric mucosa. Summary: TAB reactants in gastric mucosa significantly increased after WIRS. The total level of glutathione in the gastric mucosa was significantly lower in jaundiced rats than that in sham-operated rats and in jaundiced rats with drainage. And it significantly decreased after WIRS. UI and the level of TAB reactants in gastric mucosa significantly decreased by pretreatment with allopurinol, SOD and catalase. Present results suggest that free radicals are probably involved in the pathogenesis of AGML in obstructive jaundiced rats.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalTherapeutic Research
Volume15
Issue numberSUPPL. 1
Publication statusPublished - 1994

Keywords

  • acute gastric mucosal injury
  • free radicals
  • obstructive jaundice

ASJC Scopus subject areas

  • Medicine(all)

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