Mucosal Immunity and Mucosal Defense Mechanism - The Mechanism for Induction and Regulation of Mucosal Immune Responses

Hiroshi Nagura, Masahito Nagahashi, Yoko Nagura, Hironobu Sasano

Research output: Contribution to journalReview articlepeer-review

Abstract

The mucosal immune system forms a unique barrier system that handles a myriad of infectious and food antigens exposed to the mucosal surface, in order to prevent their invading into the tissue and producing an excessive immune response. The mucosal immune system interacts with the neuro-endocrine system through hormones in the hypothalamic-pituitary-adrenalaxis and cytokines and with energy metabolism through leptin and its receptor by the mutual expression of receptors and mutual usage of mediators. Thus, it plays an important role for the homeostasis of various gastrointestinal functions and immunologic and metabolic changes.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalBiotherapy
Volume18
Issue number1
Publication statusPublished - 2004 Jan

Keywords

  • Gut-associated lymphoid tissue
  • Hypothalamic-pituitary-adrenal axis
  • Leptin
  • Mucosal barrier
  • Mucosal immune system
  • Secretory IgA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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