Mucosal immunity against influenza induced by attenuated recombinant Sendai virus

Tadatsugu Imamura, Hitoshi Oshitani

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Evaluation of: Le TV, Mironova E, Garcin D, Compans RW. Induction of influenza-specific mucosal immunity by an attenuated recombinant Sendai virus. PLoS One 6(4), e18780 (2011). Live-attenuated influenza vaccines (LAIVs) have been shown to be more immunogenic and capable of inducing a broader immune response than inactivated vaccine. However, use of LAIVs is still limited owing to the safety concerns. Le et al. generated an attenuated recombinant Sendai virus - GP42-H1 expressing the hemagglutinin (HA) gene of influenza A virus. The HA protein was expressed on the cell surface of CV-1 cells infected with GP42-H1. Intranasal immunization of mice with GP42-H1 induced HA-specific IgG and IgA antibodies in sera and mucosal sites without causing any disease symptoms. Immunized mice were also protected from lethal dose challenge of influenza A virus.

Original languageEnglish
Pages (from-to)1393-1395
Number of pages3
JournalExpert Review of Vaccines
Volume10
Issue number10
DOIs
Publication statusPublished - 2011 Oct

Keywords

  • Sendai virus
  • influenza virus
  • live-attenuated vaccine
  • mucosal immunity
  • recombinant virus

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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