Mucoadhesion evaluation of polysaccharide gels for vaginal application by using rheological and indentation measurements

D. Pliszczak, C. Bordes, S. Bourgeois, P. Marote, H. Zahouani, S. Tupin, C. Pailler Mattei, P. Lantéri

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The influence of hyaluronic acid (HA) and fructooligosaccharides (FOS) addition on low methyl pectin (LMP) gelation has been investigated in order to produce adhesive gel-based microparticles suitable for the development of a vaginal delivery system of pro- and prebiotics. First, dynamic rheological measurements were performed on LMP/Ca 2+ gels with or without FOS and HA in presence or not of porcine stomach mucins. This rheological method is known to translate the interactions between polymer and mucins and then simulate the polymer bioadhesion potential. Nevertheless, as this method is disputed, in vitro and ex vivo indentation test measurements were also achieved in order to correlate the results obtained. Despite some different results, the overall tendency indicates that addition of HA and FOS enhanced the mucoadhesive properties of LMP gels. Moreover, gel-based microparticles obtained according to an emulsification/gelation method and composed by LMP 3% (w/v), FOS 5% (w/v) and HA 0.5% (w/v) displayed a mucoadhesive potential adapted to vaginal delivery system.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume92
DOIs
Publication statusPublished - 2012 Apr 1
Externally publishedYes

Keywords

  • Bio-adhesion measurements
  • Dynamic rheological measurements
  • Fructooligosaccharides
  • Hyaluronic acid
  • Low methyl pectin gel
  • Mucoadhesive microparticles

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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