Mucin expression in nonneoplastic and neoplastic glandular epithelia of the uterine cervix

Shumei Zhao, Tadashi Hayasaka, Mitsumasa Osakabe, Noriko Kato, Kenji Nakahara, Hirohisa Kurachi, Masayuki Fukase, Yousei Katayama, Nobuo Yaegashi, Teiichi Motoyama

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Although it is well known that the uterine cervix contains mucin-producing glandular epithelium, only a few studies have described the changes in mucin that accompany malignant transformation. In this study the authors evaluated the characteristics of mucin expression in the normal endocervical epithelium and mucinous and endometrioid adenocarcinomas of the uterine cervix. The normal endocervical epithelium was characterized by predominant sulfomucin and MUC1 expression in all sites and MUC5AC expression in the surface epithelium, while MUC2 was not detected at all and pyloric gland type mucin (using antibody HIK1083) was detected in less than 1% of cases. Cervical adenocarcinomas, especially mucinous adenocarcinomas, showed marked variability in mucin expression that included mucins of pyloric gland and intestinal type.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalInternational Journal of Gynecological Pathology
Volume22
Issue number4
DOIs
Publication statusPublished - 2003 Oct

Keywords

  • Adenocarcinoma
  • Mucin
  • Uterine cervix

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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