Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer

Kazunori Gomi, Toshiaki Kikuchi, Yutaka Tokue, Shigeru Fujimura, Akiko Uehara, Haruhiko Takada, Akira Watanabe, Toshihiro Nukiwa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C12-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-κB signaling pathway besides their quorum-sensing role, like 3-oxo-C12-HSL from Pseudomonas aeruginosa.

Original languageEnglish
Pages (from-to)7029-7031
Number of pages3
JournalInfection and immunity
Volume74
Issue number12
DOIs
Publication statusPublished - 2006 Dec

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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