MoS2@C nanosphere as near infrared / pH dual response platform for chemical photothermal combination treatment

Xiao Zhang, Zhihuan Zhao, Pengfei Yang, Wen Liu, Jimin Fan, Bing Zhang, Shu Yin

Research output: Contribution to journalArticle

Abstract

The three-dimensional urchin-like MoS2@C nanocomposite was successfully synthesized via one-step hydrothermal synthesis approach. The as-prepared MoS2@C nanoparticles exhibits strong absorb, high photothermal conversion ability (40.8 %), superb biocompatibility and high drug loading capacity for doxorubicin (52.34 %). In vitro drug release experiments show a pH, temperature and near infrared laser-triggered doxorubicinhydro release profile that enhances therapeutic anticancer effects. The drug release curve increased step by step under laser irradiation, and the accumulative delivery amount reached to 64.59 %, which was about 2 times of that without laser irradiation. By using DOX-loaded nano-platform, effective synergistic photothermal therapy for cancer can be achieved and has been systematically verified in vitro. Cell viability experiments showed that the survival rate of cells with MoS2 @C-DOX was only 25.8 %. Therefore, this work presents carbon-based nanoparticles with significant characteristics and is used as a highly potential therapeutic nano-platform for cancer treatment.

Original languageEnglish
Article number111054
JournalColloids and Surfaces B: Biointerfaces
Volume192
DOIs
Publication statusPublished - 2020 Aug

Keywords

  • Carbon sphere
  • Chemotherapy
  • MoS@C-DOX
  • Photothermal therapy

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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