Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice

Katsunori Nonogaki; Takao Kaji

doi:10.1016/j.diabres.2015.10.011

Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice

Katsunori Nonogaki, Takao Kaji

New Industry Creation Hatchery Center (NICHe)

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Pharmacologic stimulation of serotonin 5-HT4 receptors increased plasma active glucagon-like-peptide-1 (GLP-1) levels independent of feeding, and that pharmacologic stimulation of 5-HT4 receptors and pharmacologic inhibition of dipeptidyl peptidase-4 exerted synergic effects on plasma active GLP-1 levels and glucose tolerance in mice.

Original language	English
Pages (from-to)	e18-e21
Journal	Diabetes Research and Clinical Practice
Volume	110
Issue number	3
DOIs	https://doi.org/10.1016/j.diabres.2015.10.011
Publication status	Published - 2015 Dec 1

Keywords

5-HT4 receptor agonist
Alogliptin
DPP-4 inhibitor
GLP-1
Glucose tolerance
Mosapride

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2015.10.011

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Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice. / Nonogaki, Katsunori ; Kaji, Takao.

In: Diabetes Research and Clinical Practice, Vol. 110, No. 3, 01.12.2015, p. e18-e21.

Research output: Contribution to journal › Article › peer-review

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AU - Kaji, Takao

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Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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