Mosaic development of the olfactory cortex with Pax6-dependent and -independent components

Tatsumi Hirata, Tadashi Nomura, Yoshiko Takagi, Yasufumi Sato, Naomi Tomioka, Hajime Fujisawa, Noriko Osumi

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

The olfactory cortex is the target area of olfactory bulb axons and is suggested to be derived from neuroepithelial progenitors of various ventricular domains during development. In the present study, we examined the development of the olfactory cortex, using the newly developed monoclonal antibody (mAb) 9-4c, which recognizes reticulon 1-A and -B. The mAb labeled neuroepithelial progenitors at the pallio-subpallial boundary (PSB) and their putative descendants in the deep layers of the olfactory cortex. In the Pax6 mutant embryo, labeling at the PSB was specifically lacking, and the number of immunopositive cells in the olfactory cortex was markedly reduced. In contrast, the guidepost neurons of olfactory bulb axons, lot cells, developed relatively normally in the superficial layer of the olfactory cortex in the mutant embryo. These guidepost neurons have been recently shown to originate in the pallium and eventually guide the initial projection of olfactory bulb axons. The olfactory bulb projection in the Pax6 mutant embryo also suggested the dualistic nature of the olfactory cortex development; the initial projection of olfactory bulb axons developed relatively normally, whereas the final projection of their collateral branches was severely defective.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalDevelopmental Brain Research
Volume136
Issue number1
DOIs
Publication statusPublished - 2002 May 30

Keywords

  • Development
  • Lateral olfactory tract
  • Lot cell
  • Monoclonal antibody
  • Olfactory cortex
  • Pallio-subpallial boundary
  • Pax6
  • Reticulon
  • Small eye

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Mosaic development of the olfactory cortex with Pax6-dependent and -independent components'. Together they form a unique fingerprint.

Cite this