Morphological differences in innervation between mucous glands and serous glands: A quantitative histological study using the sublingual glands of elderly humans

Ai Kawamoto, Kei Kitamura, Masahito Yamamoto, Gen Murakami, Shin Ichi Abe, Yukio Katori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Conclusion: In the sublingual gland, the serous lobule usually carried a higher density of NSE-positive nerve elements than the mucous lobule, whereas the mucous acinus in the mucous lobule was larger than the serous acinus in the serous lobule. Objectives: To demonstrate quantitative differences in nerve elements between the mucous and serous lobules of sublingual glands. Methods: This study investigated using specimens from 14 donated cadavers (mean age = 78 years). Since immunohistochemistry for neuron-specific enolase (NSE) stains all nerves in addition to other mesenchymal cells possibly of nerve origin, the present quantitative evaluation was based on NSE-positive areas per visual field under a ×20 objective lens (0.6 × 0.45 mm when printed). Results: In mucous lobules, the areas occupied by NSE-positive nerve elements ranged from 5798-16,541 μm2 (mean ± SD = 9280 ± 2584 μm2). In contrast, the corresponding areas in serous lobules ranged from 7853-23,540 μm2 (mean ± SD = 13,520 ± 4351 μm2). The difference in NSE-positive areas was statistically significant (p = 0.0022). However, the mucous acinus in the mucous lobule was 2-times larger than the serous acinus in the serous lobule (2474 ± 1477 μm2 vs 1119 ± 632 μm2).

Original languageEnglish
Pages (from-to)942-949
Number of pages8
JournalActa Oto-Laryngologica
Volume135
Issue number9
DOIs
Publication statusPublished - 2015 Sep 1

Keywords

  • Human adult
  • Immunohistochemistry
  • Mucous acinus
  • Nerve
  • Serous acinus
  • Sublingual gland

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Morphological differences in innervation between mucous glands and serous glands: A quantitative histological study using the sublingual glands of elderly humans'. Together they form a unique fingerprint.

  • Cite this