Morphological characteristics in peritoneum in patients with neutral peritoneal dialysis solution

Chieko Hamada, Kazuho Honda, Kunio Kawanishi, Hirotaka Nakamoto, Yasuhiko Ito, Tsutomu Sakurada, Yudo Tanno, Toru Mizumasa, Masanobu Miyazaki, Misaki Moriishi, Masaaki Nakayama

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Peritoneal dialysis solution (PDS) plays a role in functional and morphological damage to the peritoneum. This study aimed to clarify the effect of neutral PDS in preventing morphological changes by assessing peritoneal damage and comparing morphological alterations between PD patients treated with neutral PDS and acidic PDS. Sixty-one patients participated from seven hospitals. All patients were treated with neutral PDS excluding icodextrin, during their entire PD treatment, and experienced no episode of peritonitis. The thickness of submesothelial compact (SMC) zone and the presence of vasculopathy in the anterior parietal abdominal peritoneum were assessed. The impact of icodextrin, hybrid therapy, and peritoneal rest and lavage in morphological alterations were determined. There was no significant difference in the average SMC thickness between neutral and acidic PDS. The vessel patency in patients using neutral PDS was significantly higher compared to that in acidic PDS at any time during PD. There were no significant suppressive effects from interventions or use of icodextrin with respect to peritoneal morphological injury. A monolayer of mesothelial cell was observed in approximately half the patients, especially in their receiving lavage patients. Neutral PDS, accompanied by other preventive approaches against peritoneal injury, might suppress the development of peritoneal morphological alterations.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalJournal of Artificial Organs
Issue number3
Publication statusPublished - 2015 Sep 4
Externally publishedYes


  • Hybrid therapy
  • Neutral PD solution
  • Pathological changes
  • Peritoneal dialysis
  • Peritoneal lavage

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine


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