Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair

K. N. Broadley; A. M. Aquino; S. C. Woodward; A. Buckley-Sturrock; Y. Sato; D. B. Rifkin; J. M. Davidson

Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair

K. N. Broadley, A. M. Aquino, S. C. Woodward, A. Buckley-Sturrock, Y. Sato, D. B. Rifkin, J. M. Davidson

Research output: Contribution to journal › Article › peer-review

Abstract

Exogenous polypeptide growth factors influence the rate of wound healing and other biological processes, but there is no evidence that these peptides have an intrinsic role. To test whether basic fibroblast growth factor is involved in wound repair, rats were implanted with subcutaneous polyvinyl alcohol sponges containing slow-release pellets releasing either a polyclonal neutralizing antiserum directed against basic fibroblast growth factor, preimmune IgG, or nothing. Histological and biochemical evaluation of the granulation tissue that infiltrated the sponges showed anti-basic fibroblast growth factor to cause significant reductions in DNA, protein, and collagen content when compared with either preimmune IgG or placebo at the early stages of wound repair.

Original language	English
Pages (from-to)	571-575
Number of pages	5
Journal	Laboratory Investigation
Volume	61
Issue number	5
Publication status	Published - 1989
Externally published	Yes

Keywords

Granulation tissue
Neutralizing antibody

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology

Cite this

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title = "Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair",

abstract = "Exogenous polypeptide growth factors influence the rate of wound healing and other biological processes, but there is no evidence that these peptides have an intrinsic role. To test whether basic fibroblast growth factor is involved in wound repair, rats were implanted with subcutaneous polyvinyl alcohol sponges containing slow-release pellets releasing either a polyclonal neutralizing antiserum directed against basic fibroblast growth factor, preimmune IgG, or nothing. Histological and biochemical evaluation of the granulation tissue that infiltrated the sponges showed anti-basic fibroblast growth factor to cause significant reductions in DNA, protein, and collagen content when compared with either preimmune IgG or placebo at the early stages of wound repair.",

keywords = "Granulation tissue, Neutralizing antibody",

author = "Broadley, {K. N.} and Aquino, {A. M.} and Woodward, {S. C.} and A. Buckley-Sturrock and Y. Sato and Rifkin, {D. B.} and Davidson, {J. M.}",

year = "1989",

language = "English",

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journal = "Laboratory Investigation",

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T1 - Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair

AU - Broadley, K. N.

AU - Aquino, A. M.

AU - Woodward, S. C.

AU - Buckley-Sturrock, A.

AU - Sato, Y.

AU - Rifkin, D. B.

AU - Davidson, J. M.

PY - 1989

Y1 - 1989

N2 - Exogenous polypeptide growth factors influence the rate of wound healing and other biological processes, but there is no evidence that these peptides have an intrinsic role. To test whether basic fibroblast growth factor is involved in wound repair, rats were implanted with subcutaneous polyvinyl alcohol sponges containing slow-release pellets releasing either a polyclonal neutralizing antiserum directed against basic fibroblast growth factor, preimmune IgG, or nothing. Histological and biochemical evaluation of the granulation tissue that infiltrated the sponges showed anti-basic fibroblast growth factor to cause significant reductions in DNA, protein, and collagen content when compared with either preimmune IgG or placebo at the early stages of wound repair.

AB - Exogenous polypeptide growth factors influence the rate of wound healing and other biological processes, but there is no evidence that these peptides have an intrinsic role. To test whether basic fibroblast growth factor is involved in wound repair, rats were implanted with subcutaneous polyvinyl alcohol sponges containing slow-release pellets releasing either a polyclonal neutralizing antiserum directed against basic fibroblast growth factor, preimmune IgG, or nothing. Histological and biochemical evaluation of the granulation tissue that infiltrated the sponges showed anti-basic fibroblast growth factor to cause significant reductions in DNA, protein, and collagen content when compared with either preimmune IgG or placebo at the early stages of wound repair.

KW - Granulation tissue

KW - Neutralizing antibody

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JO - Laboratory Investigation

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SN - 0023-6837

IS - 5

ER -

Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair

Abstract

Keywords

ASJC Scopus subject areas

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